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目的 探讨酒精性肝硬化患者中饮酒模式与腹水发生的危险因素分析。方法 选取2023年5月至2024年10月解放军北部战区总医院收治的115例酒精性肝硬化患者,均为男性,年龄(57.56±8.71)岁,年龄范围为34~77岁。通过问卷调查与病历回顾,统计患者入院时并发腹水情况,比较并发腹水患者与未并发腹水患者的饮酒情况及临床资料,通过logistic回归分析筛选影响酒精性肝硬化患者并发腹水的相关危险因素。结果 多因素logistic回归分析结果显示,饮酒后饮茶与酒精性肝硬化合并腹水的风险降低独立相关,居住在城镇的患者与合并腹水的风险降低独立相关(P<0.05)。结论 饮酒后饮茶与酒精性肝硬化患者发生腹水的风险降低呈独立相关,居住在城镇的酒精性肝硬化患者也与腹水风险的降低存在独立相关性。
Abstract:Objective To explore the Analysis of drinking patterns and risk factors for ascites in patients with alcoholic cirrhosis.Methods A total of 115 male patients with alcoholic cirrhosis,aged(57.56 ± 8.71)years old,ranging from 34 to 77 years old,were selected from the General Hospital of Northern Theater Command between May 2023 and October 2024. Using questionnaires and medical record reviews,the presence of ascites upon admission was recorded. Drinking patterns and clinical data were compared between patients with and without ascites,and logistic regression analysis was performed to identify relevant risk factors affecting the occurrence of ascites in patients with alcoholic cirrhosis. Results Multivariate logistic regression analysis showed that drinking tea after alcohol consumption was independently associated with a reduced risk of ascites in patients with alcoholic cirrhosis,as was living in urban areas(P<0.05). Conclusion Drinking tea after consuming alcohol is independently associated with a reduced risk of ascites in patients with alcoholic cirrhosis. Additionally,residing in urban areas is also independently associated with a reduced risk of ascites in these patients.
[1] Marot A,Henrion J,Knebel JF,et al.Alcoholic liver disease confers a worse prognosis than HCV infection and non-alcoholic fatty liver disease among patients with cirrhosis:An observational study[J].PLoS One,2017,12(10):e0186715.
[2] Julien J,Ayer T,Bethea ED,et al.Projected prevalence and mortality associated with alcohol-related liver disease in the USA,2019-40:a modelling study[J]. Lancet Public Health,2020,5(6):e316-e323.
[3] Tapper EB,Parikh ND.Diagnosis and management of cirrhosis and its complications:a review[J]. JAMA,2023,329(18):1589-1602.
[4] Wiegand J,Kühne M,Pradat P,et al.Different patterns of decompensation in patients with alcoholic vs. non-alcoholic liver cirrhosis[J].Aliment Pharmacol Ther,2012,35(12):1443-1450.
[5] Tapper EB,Zhao Z,Mazumder N,et al.Incidence of,risk factors for,and outcomes after ascites in a population-based cohort of older americans[J].Dig Dis Sci,2022,67(11):5327-5335.
[6]中华医学会,中华医学会杂志社,中华医学会消化病学分会,等.酒精性肝病基层诊疗指南(2019年)[J].中华全科医师杂志,2020,19(11):990-996.
[7] Wang H,Gao P,Chen W,et al.A cross-sectional study of alcohol consumption and alcoholic liver disease in Beijing:based on 74,998 community residents[J].BMC Public Health,2022,22(1):723.
[8] Aithal GP,Palaniyappan N,China L,et al. Guidelines on the management of ascites in cirrhosis[J].Gut,2021,70(1):9-29.
[9] Dao C,Zhou H,Small A,et al.The impact of removing former drinkers from genome-wide association studies of AUDIT-C[J].Addiction,2021,116(11):3044-3054.
[10] Wang Y,Yao Y,Chen Y,et al.Association between Drinking Patterns and Incident Hypertension in Southwest China[J].Int J Environ Res Public Health,2022,19(7):3801.
[11] Fadlallah H,El Masri D,Bahmad HF,et al.Update on the complications and management of liver cirrhosis[J]. Med Sci(Basel),2025,13(1):13.
[12] Li Z,Zhu J,Ouyang H.Recent insights into contributing factors in the pathogenesis of cirrhotic ascites[J]. Front Med(Lausanne),2024,11:1376217.
[13] Kamezaki H,Iwanaga T,Maeda T,et al.A comparison of the effects of alcohol abstinence and drinking habit on the survival of patients with alcohol-related cirrhosis:a retrospective observational study[J].Intern Med,2025,64(5):625-629.
[14] Simpson RF,Hermon C,Liu B,et al.Alcohol drinking patterns and liver cirrhosis risk:analysis of the prospective UK Million Women Study[J].Lancet Public Health,2019,4(1):e41-e48.
[15] Idelfonso-García OG,Alarcón-Sánchez BR,Guerrero-Escalera D,et al.Nucleoredoxin redox interactions are sensitized by aging and potentiated by chronic alcohol consumption in the mouse liver[J].Antioxidants(Basel),2024,13(3):257.
[16] Wu X,Fan X,Miyata T,et al.Recent advances in understanding of pathogenesis of alcohol-associated liver disease[J]. Annu Rev Pathol,2023,18:411-438.
[17] Hagstr?m H,Hemmingsson T,Discacciati A,et al.Alcohol consumption in late adolescence is associated with an increased risk of severe liver disease later in life[J]. J Hepatol,2018,68(3):505-510.
[18] Whitfield JB,Masson S,Liangpunsakul S,et al.Obesity,diabetes,coffee,tea,and cannabis use alter risk for alcohol-related cirrhosis in 2 large cohorts of high-risk drinkers[J].Am J Gastroenterol,2021,116(1):106-115.
[19] Yu J,Liang D,Li J,et al.Coffee,Green Tea Intake,and the Risk of Hepatocellular Carcinoma:A Systematic Review and Meta-Analysis of Observational Studies[J].Nutr Cancer,2023,75(5):1295-1308.
[20] Tang Z,Zhan L,He R,et al.Hepatoprotective effect of tea composite solid beverage on alcohol-caused rat liver injury[J].Foods,2023,12(22):4126.
[21] Xu KH,Yang DF,Liu MY,et al.Hepatoprotective effects and mechanisms of l-theanine and epigallocatechin gallate combined intervention in alcoholic fatty liver rats[J].J Sci Food Agric,2024,104(13):8230-8239.
[22] Saimaiti A,Zhou DD,Li J,et al.Dietary sources,health benefits,and risks of caffeine[J].Crit Rev Food Sci Nutr,2023,63(29):9648-9666.
基本信息:
DOI:10.16048/j.issn.2095-5561.2025.05.01
中图分类号:R575.2
引用信息:
[1]丁思元,卢盛言,李佳宇,等.酒精性肝硬化患者饮酒模式与腹水发生的危险因素分析[J].创伤与急危重病医学,2025,13(05):321-325.DOI:10.16048/j.issn.2095-5561.2025.05.01.