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目的 探讨影响脓毒症发生深静脉血栓（DVT）的因素。方法 本研究为回顾性病例对照研究，选取2019年4月至2024年6月厦门大学附属翔安医院收治的160例脓毒症患者，男性71例，女性89例，年龄（72.4±6.4）岁，年龄范围为61～82岁。根据患者是否发生DVT分为合并DVT组（n=50）和未合并DVT组（n=110）。采用单因素及多因素Logistic回归分析筛选影响脓毒症发生DVT的危险因素，使用受试者操作特征曲线分析各危险因素及联合指标的诊断效能。结果 Logistic回归结果显示，合并糖尿病（OR=3.009,95%CI:1.191～7.604）、合并下肢功能障碍（OR=6.790,95%CI:2.740～16.828）、D-二聚体升高（OR=6.173,95%CI:2.606～14.625）和住院期间手术（OR=2.379,95%CI:1.034～5.471）是影响脓毒症发生DVT的独立危险因素（P<0.05）。上述四种因素均对其诊断效能具有较高的影响，联合检测诊断效能更高（P<0.05）。结论 合并糖尿病、合并下肢功能障碍、D-二聚体升高和住院期间手术是影响脓毒症发生DVT的独立危险因素，对其具有较高的诊断效能，联合检测优于单独评价。
Abstract：Objective This study aims to explore the risk factors influencing the occurrence of deep vein thrombosis(DVT) in patients with sepsis. Methods This study was a retrospective case-control study,a total of 160 patients with sepsis were selected from Xiang'an Hospital of Xiamen University from April 2019 to June 2024,including71 males and 89 females,aged(72.4 ± 6.4) years old,ranging form 61 to 82 years old. Based on whether the patients subsequently developed DVT, they were divided into the DVT group(n=50) and the non-DVT group(n=110).Univariate and multivariate Logistic regression analyses were conducted to identify the risk factors affecting the occurrence of DVT in sepsis patients. The diagnostic efficacy of each risk factor and the combined indicators was analyzed using the receiver operating characteristic curve. Results Logistic regression results indicated that diabetes(OR=3.009,95%CI:1.191 to 7.604),lower limb dysfunction(OR=6.790,95%CI:2.740 to 16.828),elevated D-dimer(OR=6.173,95%CI:2.606 to 14.625),and surgery during hospitalization(OR=2.379,95%CI:1.034 to 5.471)were independent risk factors for the occurrence of DVT in sepsis(P<0.05). Each of the above four factors had a high impact on diagnostic efficacy,the combined detection had an even higher diagnostic efficacy(P<0.05). Conclusion Diabetes,lower limb dysfunction,elevated D-dimer,and surgery during hospitalization are independent risk factors affecting the occurrence of DVT in sepsis patients and have high diagnostic efficacy,with combined detection outperforming individual assessments.
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基本信息:
DOI：10.16048/j.issn.2095-5561.2026.02.02
中图分类号:R459.7
引用信息:
[1]邱星强,郑和平,任晓媛,等.脓毒症患者深静脉血栓形成的危险因素及其对临床决策的影响[J].创伤与急危重病医学,2026,14(02):71-75.DOI:10.16048/j.issn.2095-5561.2026.02.02.
基金信息:
福建省自然科学基金项目（2024J08006）; 厦门市医疗卫生指导性项目（3502Z20254ZD1257）
2026-02-25
2026-02-25